Hormonal regulation of cardiac KCNE2 gene expression
نویسندگان
چکیده
منابع مشابه
Nutrient and hormonal regulation of pyruvate kinase gene expression.
Mammalian pyruvate kinase (PK), a key glycolytic enzyme, has two genes named PKL and PKM, which produce the L- and R-type isoenzymes by means of alternative promoters, and the M1-and M2-types by mutually exclusive alternative splicing respectively. The expression of these genes is tissue-specific and under developmental, dietary and hormonal control. The L-type isoenzyme (L-PK) gene contains mu...
متن کاملHormonal regulation of regucalcin gene expression: involvement in cell metabolism
Regucalcin (RGN/SMP30) and its gene (rgn)are identified in over 15 species consisting of regucalcin family, and its gene is localized on X chromosome. Regucalcin has been shown to play a multifunctional role in many tissues and cell types. Hormonal regulations of regucalcin gene expression are mediated through various transcription factors (including AP-1, NF1-A1, RGPR-p117 and other), which ar...
متن کاملDietary and hormonal regulation of aldolase B gene expression.
Aldolase B is an enzyme of the glycolytic pathway whose activity and mRNA levels in the liver fluctuate according to dietary status. Both the enzyme activity and the mRNA concentration decline during fasting and increase four- to eightfold upon refeeding of a carbohydrate-rich diet. The mechanism, however, of the mRNA induction remains unknown. To elucidate the mechanisms that regulate this ind...
متن کاملHormonal regulation of steroidogenic enzyme gene expression in Leydig cells.
In normal mouse Leydig cells, steady state levels of mRNA of CYP11A, 3β-hydroxysteroid dehydrogenase Δ⁵- >Δ⁴-isomerase (3βHSD), and CYP17 are differentially regulated. There is high basal expression of 3βHSD and CYP11A mRNA, while expression of CYP17 mRNA is absolutely dependent on cAMP stimulation. cAMP is required for maximal expression of all three enzymes. The expression of CYP11A in normal...
متن کاملSumoylation and regulation of cardiac gene expression.
Sumoylation is a posttranslational modification process in which SUMO proteins are covalently and reversibly conjugated to their targets via enzymatic cascade reactions. Since the discovery of SUMO-1 in 1996, the SUMO pathway has garnered increased attention due to its role in a number of important biological activities such as cell cycle progression, epigenetic modulation, signal transduction,...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular and Cellular Endocrinology
سال: 2008
ISSN: 0303-7207
DOI: 10.1016/j.mce.2008.06.003